(KTEN) -- Many suffering from headaches, fever or body aches when contracting COVID-19 reach for over the counter painkiller as a traditional remedy. But should you take these meds before or after getting that vaccine?

"The vaccine should produce a moderate to mild immune response, that should be anticipated," said Dr. Alex Roby with Red River ER. "You should treat you symptoms accordingly and as you would if you were suffering from a viral illness you'll want to allocate time for rest and hydration."

The go-to remedy for pain or fever --  popping Advil or Tylenol, but there is some hesitancy on what one medication could do to another.

"There shouldn't be any negative consequence of taking any over the counter medicine such as Tylenol or ibuprofen prior to receiving your vaccine, you'll still elicit the same immune response," said Dr. Roby.

Not all doctors agree. Some say, although evidence is limited, some pain killers might interfere with the very thing the vaccine is trying to do -- generate a strong immune response.

"The recommendations are very strong on not to preventively take any of those medications, because we do not know what the efficacy is going to be or if your body's immunity is going to be turned down to get the effectiveness of the vaccine," said Dr. Minaxi Rathod, an infectious disease specialist.

Not enough research to say pain killers have no negative effects on vaccines, but this is a preventative measure healthcare workers say you should take.

"If we can prevent taking something that is not needed or is a prophylactic, then we want to maximize the efficacy of the vaccine later," Dr. Rathod added.

If you have questions about how the vaccine reacts to certain medications, be sure and check with your doctor.