The Lady Tigers, who fell to 7-12 overall and 1-4 in the LSC North, saw the Lions snatch 28 offensive rebounds to keep several possessions alive and pull away late.
Senior Kacey Thomas posted a double-double with 21 points and 10 rebounds to go along with five assists to pace ECU while sophomore Casi Rawls also finished with 15 points to go with seven boards and a pair of assists.
But A&M-Commerce, 12-6 and 4-1, was so dominant in the rebounding department that three players reached double digits.
Britney Jordan led the Lions with a game-high 21 points and 10 boards while Ashley Murphy tallied 19 points and pulled down 12 rebounds. Nola Taylor also grabbed 13 boards to go with seven points for A&M-Commerce. Desiree Waller also contributed 17 points for the winners.
Veronica Valles and Laura Harris also finished with 13 apiece for the Lady Tigers and Kelcie Nunley added 10. Valles sank three 3-pointers in the contest and Harris nailed two. Nunley was a perfect 8-of-8 from the free-throw line.
However, ECU managed to convert just 35.1 percent of its shots while the Lions hit at only a 30.9 percent pace.
The Lady Tigers trailed 33-26 at the break and were down by a 41-30 margin at one point early in the second half before staging a nice comeback and even tying it up at 43-all on an old-fashioned 3-point play by Thomas.
But A&M-Commerce, clinging to a 53-51 edge, went on a 11-0 run in a three-plus minute span to take control of the game at 64-51 with 5:23 to go. Jordan knocked down a trey and four free throws during that stretch to lead the charge. Jordan was 9-of-10 from the line for the game.
ECU visits Southwestern Oklahoma State for another LSC North contest on Saturday at 2 p.m. in Weatherford.